Publications
2023
Attachaipanich S, Ozawa T, Macpherson T*, Hikida T*. (2023) Dual roles for nucleus accumbens core dopamine D1 receptor-expressing neurons projecting to the substantia nigra pars reticulata in limbic and motor control in male mice. eNeuro
https://doi.org/10.1523/ENEURO.0082-23.2023
*Co-Senior Author
Nishioka T, Suthinee A, Hamaguchi K, Lazarus M, de Kerchove d'Exaerde A, Macpherson T*, Hikida T*. (2023) Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition based choice behavior in mice. Nature Communications, 14:2284
https://doi.org/10.1038/s41467-023-38025-3
*Co-Senior Author
Macpherson T, Niwa M, Morishita H, Hikida T. (2023) .Circuit, molecular, and developmental mechanisms in decision-making behavior. Frontiers in Neuroscience
https://doi.org/10.3389/fnins.2023.1192237
Attachaipanich S, Ozawa T, Macpherson T*, Hikida T*. (2023) Dual roles for nucleus accumbens core dopamine D1 receptor-expressing neurons projecting to the substantia nigra pars reticulata in limbic and motor control. BioXriv (Preprint)
*Co-Senior Author
2022
Saito N, Itakura M, Tainaka K, Macpherson T, Hikida T, Yamaguchi S, Sato A, Okubo T, Chicken S, Nanbu S, Sasaoka T. (2022) Elucidating the role of neurotransmission via D1 and D2 dopamine receptors in the mechanisms of motor control, learning, and memory. Japanese Journal of Biological Psychiatry
Macpherson T, Kim J, Hikida T. (2022) Nucleus accumbens core dopamine D2 receptor-expressing neurons control reversal learning but not set-shifting in behavioral flexibility in male mice. Frontiers in Neuroscience
https://doi.org/10.3389/fnins.2022.885380
Aomine Y, Sakurai K, Macpherson T, Ozawa T, Miyamoto Y, Yoneda Y, Oka M, Hikida T. (2022) Importin α3 (KPNA3) deficiency augments effortful reward-seeking behavior in mice. Frontiers in Neuroscience, 16:905991
https://doi.org/10.3389/fnins.2022.905991
Nishioka T, Macpherson T, Hamaguchi K, Hikida T. (2022) Error-related Signaling in Nucleus Accumbens D2 Receptor-expressing Neurons Guides Avoidance-based Goal-directed Behavior. BioRxiv, (Preprint)
2021
Macpherson T, Churchland A, Sejnowski T, DiCarlo J, Kamitani Y, Takahashi H, Hikida T. (2021) Natural and Artificial Intelligence: a brief introduction to the interplay between AI and neuroscience research. Neural Networks, 144:603-613.
Macpherson T, Matsumoto M, Gomi, H, Morimoto J, Uchibe E, Hikida T. (2021) Parallel and hierarchical neural mechanisms for adaptive and predictive behavioral control. Neural Networks, 144:507-521.
Sakurai K, Itou T, Morita M, Kasahara E, Moriyama T, Macpherson T, Ozawa T, Miyamoto Y, Yoneda Y, Sekiyama A, Oka M, Hikida T. (2021) Effects of Importin α1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice. Plos One, 16(11): e0258364.
Nishioka T, Macpherson T, Hamaguchi K, Hikida T. (2021) Distinct Roles of Dopamine D1 and D2 Receptor-expressing Neurons in the Nucleus Accumbens for a Strategy Dependent Decision Making. BioRxiv, (preprint).
2020
Saito N, Tainaka K, Macpherson T, Hikida T, Yamaguchi S, Sasaoka T. (2020) Neurotransmission through dopamine D1 receptors is required for aversive memory formation and Arc activation in the cerebral cortex. Neuroscience Research, 156:58-65.
Hikida T*, Yao S*, Macpherson T*, Fukakusa A, Morita M, Kimura H, Hirai K, Ando T, Toyoshiba H, Sawa A. (2020) Nucleus accumbens pathways control cell-specific gene expression in the medial prefrontal cortex. Scientific Reports, 10(1): 1838.
*co-first authorship
Hikida T, Morita M, Kuroiwa M, Macpherson T, Shuto T, Sotogaku N, Niwa M, Sawa A, Nishi A. (2020) Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice. Neuroscience Research, 151: 38-45.
2019
Macpherson T, Hikida T. (2019) Response to “Mood and Affect”. Psychiatry and Clinical Neuroscience, 73(6): 347-347.
Macpherson T, Mizoguchi H, Yamanaka A, Hikida T. (2019) Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning. Neurochemistry International, 126: 11-18.
Macpherson T, Hikida T. (2019) Role of basal ganglia neurocircuitry in the pathology of psychiatric disorders. Psychiatry and Clinical Neuroscience, 73(6): 289-301.
2018
Macpherson T, Hikida T. (2018) Nucleus accumbens dopamine D1-receptor-expressing neurons control the acquisition of sign-tracking to conditioned cues in mice. Frontiers in Neuroscience, 12: 418.
2017
Hikida T, Macpherson T, Morita M. (2017) Basal Ganglia Circuit Mechanisms in Cognitive Learning. Japanese Journal of Psychopharmacology. 37(2) 35-8.
2016
Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A, Hikida T. (2016) Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage. Learning and Memory, 23 (7): 359-364.
Hikida T, Morita M, Macpherson T. (2016) Neural mechanisms of the nucleus accumbens circuit in reward and aversive learning. Neuroscience Research, 108: 1-5.
Macpherson T, Dixon CI, Janak PH, Belelli D, Lambert JJ, Stephens DN, King SL (2016) α4-containing GABAA receptors on dopamine D2 receptor-expressing neurons mediate instrumental responding for conditioned reinforcers, and its potentiation by cocaine. BioRxiv (preprint)
2014
Macpherson T, Morita M, Hikida T. (2014) Striatal direct and indirect pathways control decision-making behavior. Frontiers in Psychology, 5: 1301.
Maguire EP*, Macpherson T*, Swinny JD*, Dixon CI, Herd MB, Belelli D, Stephens DN, King SL, Lambert JJ. (2014). Tonic inhibition of accumbal spiny neurons by extrasynpatic α4βδ GABAA receptors modulates the actions of psychostimulants. Journal of Neuroscience, 34(3): 823-838.
*co-first authorship
2011
Brown D, Macpherson T, Ward J (2011). Seeing with sound? Exploring different characteristics of a visual-to-auditory sensory substitution device. Perception, 40(9): 1120-35.